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10.1289/ehp.94102s1085

10.3389/fimmu.2022.888392 2 AtasN.ErogluG

In hypothalamic pro-opiomelanocortin (POMC) neurons, knockdown of family with sequence similarity 172 member A (Fam172a) stimulates glycolysis and increases the levels of peptidylglycine -amidating monooxygenase (PAM), which affects the synthesis of -melanocyte-stimulating hormone (-MSH) via H4K12la, eventually exerting an anti-obesity effect

Extracellular deposition of -amyloid (A plaques), intraneuronal tau accumulation, inflammation (activated astrocytes and microglia), and neuronal loss are all consistent pathological features of the disease (Porquet et al., 2015)

Regulation of inflammatory signalling pathways